반응 #43759

반응 방정식

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride

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title compound

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-amino-1-benzothiophene-2-carboxamide dihydrochloride

용매

tin(II) chloride

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture is purified by preparative HPLC
2. 2
   농축The product fractions are concentrated
3. 3
   workup.DISSOLUTIONdissolved in a mixture of methanol and 4M HCl in dioxane
4. 4
   농축again concentrated
5. 5
   기타dried under high vacuum

실험 절차

83 mg (0.23 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride are dissolved in 1.5 ml of 2M tin(II) chloride solution in DMF and stirred at RT for 14 h. The reaction mixture is purified by preparative HPLC. The product fractions are concentrated, dissolved in a mixture of methanol and 4M HCl in dioxane, then again concentrated and dried under high vacuum. 53 mg (57.2% of theory) of the title compound are obtained.

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