반응 #43725

반응 방정식

methyl chloroacetate

2-hydroxy-4-nitrobenzaldehyde

potassium carbonate

hydrochloric acid

potassium hydroxide

→

title compound

6-Nitro-1-benzofuran-2-carboxylic acid

용매

water

THF

반응 조건

후처리

1. 1
   추출The mixture is extracted with ethyl acetate
2. 2
   세척The organic phase is washed with water
3. 3
   건조dried over sodium sulfate
4. 4
   workup.ADDITIONthe addition of silica gel
5. 5
   농축the mixture is concentrated
6. 6
   기타chromatographed on silica gel (mobile phase gradient: toluene to toluene/methanol/glacial acetic acid 35:5:1)
7. 7
   기타Concentration of the product fractions and drying under reduced pressure

실험 절차

5.8 g (34.7 mmol) of 2-hydroxy-4-nitrobenzaldehyde, 1.28 g (3.5 mmol) of tetra-N-butylammonium iodide and 19.2 g (138.8 mmol) of potassium carbonate are mixed, 7.9 g (72.9 mmol) of methyl chloroacetate are added and the mixture is heated at 130° C. for 12 h. 100 ml of THF and, with ice cooling, 11.7 g (208.2 mmol) of potassium hydroxide are added. Following the addition of 100 ml of water, the mixture is stirred at RT for 20 h. Using concentrated hydrochloric acid, the pH is adjusted to 0. The mixture is extracted with ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. Following the addition of silica gel, the mixture is concentrated and chromatographed on silica gel (mobile phase gradient: toluene to toluene/methanol/glacial acetic acid 35:5:1). Concentration of the product fractions and drying under reduced pressure gives 1.31 g (18.2% of theory) of the title compound.

출처