반응 #43707

반응 방정식

2,4-dinitrobenzaldehyde

methyl mercaptoacetate

triethylamine

→

Methyl6-nitro-1-benzothiophene-2-carboxylate

용매

DMSO

반응 조건

후처리

1. 1
   여과The resulting precipitate is filtered off with suction
2. 2
   세척washed with water
3. 3
   기타dried at 50° C. under reduced pressure overnight

실험 절차

24.8 g (126.7 mmol) of 2,4-dinitrobenzaldehyde, 13.4 g (126.7 mmol) of methyl mercaptoacetate and 35.3 ml (253.3 mmol) of triethylamine in 74.5 ml of DMSO are heated at 80° C. for 1 h. The reaction solution is poured into 250 ml of ice-water. The resulting precipitate is filtered off with suction, washed with water and dried at 50° C. under reduced pressure overnight. This gives 16.1 g (53.6% of theory) of the title compound.

출처