반응 #43706

반응 방정식

water

potassium carbonate

methyl mercaptoacetate

3-methoxy-2-nitrobenzaldehyde

→

Methyl7-methoxy-1-benzothiophene-2-carboxylate

용매

DMF

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   여과The resulting precipitate is filtered off
3. 3
   세척washed with water
4. 4
   기타dried under reduced pressure

실험 절차

550 mg (3.97 mmol) of potassium carbonate and 350 mg (3.31 mmol) of methyl mercaptoacetate are added to a solution of 600 mg (3.31 mmol) of 3-methoxy-2-nitrobenzaldehyde in 8 ml of DMF. The reaction mixture is heated at 70° C. for 4 h. After cooling, water is added. The resulting precipitate is filtered off, washed with water and dried under reduced pressure. This gives 387 mg (45.7% of theory) of the title compound.

출처