반응 #43705

반응 방정식

4-cyano-2-nitrobenzaldehyde

methyl mercaptoacetate

triethylamine

acetic acid

→

Methyl6-cyano-1-benzothiophene-2-carboxylate

용매

DMSO

반응 조건

후처리

1. 1
   여과the resulting precipitate is filtered off with suction
2. 2
   세척washed twice with water
3. 3
   기타dried at 50° C. under reduced pressure overnight

실험 절차

4.08 g (23.2 mmol) of 4-cyano-2-nitrobenzaldehyde, 2.46 g (23.2 mmol) of methyl mercaptoacetate and 6.46 ml (46.4 mmol) of triethylamine in 12.3 ml of DMSO are heated at 80° C. for 2.5 h. The reaction solution is poured into 400 ml of ice-water. After addition of 4 ml of acetic acid, the resulting precipitate is filtered off with suction, washed twice with water and dried at 50° C. under reduced pressure overnight. This gives 4.19 g (83.2% of theory) of the title compound.

출처