반응 #43666

반응 방정식

Clopidogrel

benzene sulphonic acid

→

Clopidogrel besylate

용매

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   여과The white solid was collected by filtration
2. 2
   세척washed with diethyl ether
3. 3
   기타dried at 50-60° C. in a vacuum oven

실험 절차

Clopidogrel base was dissolved in diethyl ether at 20-25° C. To this was added benzene sulphonic acid dissolved in diethyl ether. The reaction mixture was stirred at 25-30° C. for 24-30 hrs. The white solid was collected by filtration, washed with diethyl ether, and dried at 50-60° C. in a vacuum oven to obtain Clopidogrel besylate crystalline form.

출처