반응 #43630

반응 방정식

7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone

acetic acid

tetrabutylammonium fluoride

→

desired product

수율 80.3%

7-(hydroxymethyl)-2,3-dihydro-5(1H)-indolizinone

수율 80.3%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타before being evaporated
2. 2
   기타The residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane

실험 절차

A solution of 7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone (3.93 g, 14.09 mmol) in tetrahydrofuran (100 ml) was treated with acetic acid (1.61 ml, 28.17 mmol) and tetrabutylammonium fluoride (1M in THF, 21 ml, 21.13 mmol) and stirred at room temperature for 1 h before being evaporated. The residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane to give the desired product (1.87 g, 80%)

출처