반응 #43599

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4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxaldehyde

→

title compound

수율 69.0%

3-Chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Hydrochloride

수율 69.0%

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실험 절차

The free base of the title compound was synthesised from 4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxaldehyde (for a synthesis see WO2002056882, Example 5(b)), according to the general method of Example 2(h), in 69% yield.

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