반응 #43586

반응 방정식

3-fluoro-4,5-dihydroxybenzaldehyde

potassium carbonate

1,2-dibromoethane

→

desired compound

수율 95.4%

8-fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde

수율 95.4%

용매

DMF

반응 조건

후처리

1. 1
   기타was removed under reduced pressure
2. 2
   workup.ADDITIONThe reaction mixture was then treated with dichloromethane and water
3. 3
   추출The aqueous phase was extracted twice with dichloromethane
4. 4
   기타the combined organic phases were dried
5. 5
   기타the solvent was removed under reduced pressure

실험 절차

To a solution of 3-fluoro-4,5-dihydroxybenzaldehyde (0.66 g, 4.2 mmol) in DMF (30 ml) was added potassium carbonate (1.15 g, 8.3 mmol) and 1,2-dibromoethane (0.72 ml, 8.3 mmol) and the resultant mixture was heated to 80° C. for 18 h before the solvent was removed under reduced pressure. The reaction mixture was then treated with dichloromethane and water. The aqueous phase was extracted twice with dichloromethane and the combined organic phases were dried and the solvent was removed under reduced pressure to give the desired compound as a cream solid (0.73 g, 95%).

출처