반응 #435585

반응 방정식

3-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]pyrrolidine

4-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]-2-pyrrolidone

→

title compound

수율 99.9%

3-(R)-[1-(tert-Butoxycarbonyl)amino-1-cyclobutyl]methylpyrrolidine

수율 99.9%

용매

ethanol

반응 조건

후처리

1. 1
   여과The reaction solution was filtered
2. 2
   기타the solvent was removed under reduced pressure

실험 절차

To an ethanol (30 ml) solution of 3-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]pyrrolidine (isomer B1) (516 mg, 1.44 mmol) was added a 10% palladium-carbon catalyst (water content 53.8%, 500 mg) and catalytic hydrogenation was carried out under heating at an outer temperature of 50° C. at normal pressure for 5 hours. The reaction solution was filtered and the solvent was removed under reduced pressure to obtain the title compound (366 mg, quantitative) as colorless crystals.

출처