반응 #43513

반응 방정식

4-hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

4-iodo-benzoic acid methyl ester

1-bromo-2-(4-chloro-phenylsulfanyl)-5-(trifluoromethyl)-benzene

→

1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol

반응 조건

실험 절차

1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol (intermediate for 4a) was prepared from 4-hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester, and 4-iodo-benzoic acid methyl ester by the palladium-catalysed coupling procedure described for 1-bromo-2-(4-chloro-phenylsulfanyl)-5-(trifluoromethyl)-benzene.

출처