반응 #434839

반응 방정식

2-methylene-3-quinuclidinone dihydrate hydrochloride

K2CO3

CH2Cl2

→

2-methylenequinuclidin3-one

수율 100.0%

용매

water

반응 조건

후처리

1. 1
   기타the layers are separated
2. 2
   추출the aqueous layer is extracted with CH2Cl2
3. 3
   건조The combined organic layers are dried (MgSO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

A mixture of 2-methylene-3-quinuclidinone dihydrate hydrochloride (27.2 g, 0.13 mol, 1 eq) and K2CO3 (86.0 g, 0.62 mol, 4.8 eq) is dissolved in 130 mL water and 250 mL CH2Cl2 and stirred vigorously. After 3 days, the layers are separated and the aqueous layer is extracted with CH2Cl2. The combined organic layers are dried (MgSO4), filtered and concentrated to give 17.8 g (100%) of 2-methylenequinuclidin3-one as a yellow oil. MS (ESI) for C8H11NO m/z 138.1 (M+).

출처