반응 #434822

반응 방정식

carboxylic acid

4Cyano-3methylbenzoic acid

2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

→

1-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

반응 조건

후처리

1. 1
   기타The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 50:50)

실험 절차

The carboxylic acid from Example C (0.65 g, 4.03 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine from Example 15A (0.50 g, 3.36 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 50:50); yield 0.36 g (37%).

출처