반응 #43451

반응 방정식

2,3-dihydro-1-benzofuran-5-carbaldehyde

sodium acetate

bromine

→

desired compound

수율 91.3%

7-bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde

수율 91.3%

용매

acetic acid

sodium thiosulfate

반응 조건

후처리

1. 1
   세척washed with a saturated aqueous solution of sodium bicarbonate
2. 2
   추출extracted with ethyl acetate
3. 3
   건조dried over sodium sulfate
4. 4
   기타dried in vacuo

실험 절차

To a solution of 2,3-dihydro-1-benzofuran-5-carbaldehyde (1.0 g, 6.75 mmol) in glacial acetic acid (8 ml) was added sodium acetate (664 mg, 8.1 mmol) and bromine (0.7 ml, 13.5 mmol) at 10° C. slowly. The reaction was stirred for 2 h at room temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 ml), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%).

출처