반응 #43436

반응 방정식

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

triethylsilane

trifluoroacetic acid

→

{5-Hydroxy-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate trifluoroacetate salt

용매

dichloromethane

반응 조건

후처리

1. 1
   기타After 16 hours the mixture was evaporated
2. 2
   기타triturated with toluene/ethyl acetate (250 ml/5 ml)
3. 3
   기타affording a white solid
4. 4
   기타that was isolated by filtration
5. 5
   기타dried in vacuo (22.5 g)

실험 절차

A solution of {5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (26.3 g, 67 mmol) in dichloromethane (700 ml) was treated with triethylsilane (10 ml, 62.6 mmol)and trifluoroacetic acid (35 ml). After 16 hours the mixture was evaporated and triturated with toluene/ethyl acetate (250 ml/5 ml) affording a white solid that was isolated by filtration and dried in vacuo (22.5 g).

출처