반응 #434160

반응 방정식

NaOMe

intermediate ( 55 )

[2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride

→

(4-chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]-methanone

수율 62.0%

용매

methanol

methanol

반응 조건

후처리

1. 1
   여과The precipitate was filtered off
2. 2
   세척washed with ethanol
3. 3
   기타dried
4. 4
   기타the layers were separated
5. 5
   건조The organic layer was dried (MgSO4)
6. 6
   여과filtered off
7. 7
   기타evaporated till dryness

실험 절차

NaOMe, 30% methanol (300 ml) was added to a mixture of intermediate (55) (0.127 mol) in methanol (285 ml) and the mixture was stirred at 80° C. for one night. The precipitate was filtered off, washed with ethanol and dried. The product (44.8 g, 87%) was taken up in DCM and the layers were separated. The organic layer was dried (MgSO4), filtered off and evaporated till dryness, yielding 32.3 g (62%) of (4-chlorophenyl)[4-(3-chlorophenyl)-2-methoxy-6-quinolinyl]-methanone (intermediate 56).

출처