반응 #434159

반응 방정식

6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone

phosphoryl chloride

→

[2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride

수율 100.0%

반응 조건

후처리

1. 1
   workup.STIRRINGstirred further at 70° C. for one night
2. 2
   기타evaporated till dryness

실험 절차

A mixture of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone (0.127 mol), described in International Patent Specification WO 97/21701, in phosphoryl chloride (125 ml) was stirred and heated at 40° C. for one night, stirred further at 70° C. for one night and evaporated till dryness, yielding (100%) of [2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride (1:1) (intermediate 55).

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