반응 #43380

ord-1048e2e281ec483fb3412695eaac9f3d

반응 방정식

O=C(O)c1ccc([N+](=O)[O-])cc1Br
2-bromo-4-nitro-benzoic acid
C1CCNC1
pyrrolidine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM
→
O=C(c1ccc([N+](=O)[O-])cc1Br)N1CCCC1
3-bromo-4-(pyrrolidin-1-yl-carbonyl)-1-nitro-benzene

반응물

O=C(O)c1ccc([N+](=O)[O-])cc1Br
2-bromo-4-nitro-benzoic acid
C1CCNC1
pyrrolidine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM

시약

없음

용매

CN(C)C=O
DMF

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Prepared analogously to Example 1a from 2-bromo-4-nitro-benzoic acid and pyrrolidine with TBTU and NMM in DMF.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07732466B2uspto-grants-2010_06