반응 #433594

반응 방정식

hydrazine hydrate

4-(phenylamino)-6-nitroquinazoline

iso-propylalcohol

→

4-(phenylamino)-6-aminoquinazoline

용매

ethanol water

반응 조건

후처리

1. 1
   여과The reaction mixture is filtered
2. 2
   기타evaporated
3. 3
   기타purified by silica gel chromatography

실험 절차

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

출처