반응 #43358

반응 방정식

Trifluoroacetic acid

4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one

→

title compound

수율 105.6%

4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one

수율 105.6%

용매

chloroform

반응 조건

후처리

1. 1
   농축After concentrating
2. 2
   기타the reaction liquid, 1N sodium hydroxide solution
3. 3
   workup.ADDITIONwas added
4. 4
   추출followed by extraction with chloroform two times
5. 5
   세척The organic layer was washed with saturated brine
6. 6
   건조dried over anhydrous potassium carbonate
7. 7
   농축the solvent was concentrated under reduced pressure

실험 절차

Trifluoroacetic acid (20 mL) was added to chloroform solution (20 mL) of 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one (3.14 g, Example 121), and stirred at room temperature for an hour. After concentrating the reaction liquid, 1N sodium hydroxide solution was added thereto, followed by extraction with chloroform two times. The organic layer was washed with saturated brine, dried over anhydrous potassium carbonate, and the solvent was concentrated under reduced pressure to provide the title compound (2.65 g, 83%).

출처