반응 #4335

반응 방정식

4,5-dichloro-2-nitro-N-β-aminoethylaniline

monoethanolamine

→

2-chloro-5-β-aminoethylamino-4-nitro-N-(β-hydroxyethyl)aniline

용매

water

반응 조건

후처리

1. 1
   기타An impurity is precipitated
2. 2
   workup.ADDITIONby adding hydrochloric acid
3. 3
   기타is removed by filtration
4. 4
   기타The expected product precipitates
5. 5
   여과After filtration
6. 6
   기타drying
7. 7
   기타it is purified as its hydrochloride
8. 8
   기타before being recrystallized from alcohol

실험 절차

0.04 mole (10 g) of 4,5-dichloro-2-nitro-N-β-aminoethylaniline prepared in the 1st stage is heated in 40 ml of monoethanolamine for 30 minutes to 100° C. The reaction mixture is diluted with 450 ml of iced water. An impurity is precipitated by adding hydrochloric acid and is removed by filtration. The filtrate is made alkaline with concentrated sodium hydroxide solution. The expected product precipitates. After filtration and drying, it is purified as its hydrochloride before being recrystallized from alcohol. It melts at 160° C.

출처