반응 #433420

반응 방정식

ethyl homovanillate

1-bromo-3-chloropropane

potassium carbonate

→

title compound

수율 65.1%

4-(3-Chloropropoxy)-3-methoxybenzeneacetic acid ethyl ester

수율 65.1%

용매

acetone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 24 hr
3. 3
   여과The mixture was filtered
4. 4
   농축the filtrate was concentrated under reduced pressure
5. 5
   기타to give an oil which
6. 6
   기타gradually crystallized to a semi-solid
7. 7
   기타The solid was recrystallized from ethyl ether-petroleum ether (30°-60°)

실험 절차

A mixture of 50 g (0.238 mole of ethyl homovanillate (98% Aldrich), 75 g (0.476 mole) of 1-bromo-3-chloropropane and 98.7 g (0.71 mole) of anhydrous potassium carbonate in 1 L of acetone was heated at reflux for 24 hr. The mixture was filtered and the filtrate was concentrated under reduced pressure to give an oil which gradually crystallized to a semi-solid. The solid was recrystallized from ethyl ether-petroleum ether (30°-60°) to yield 44.4 g (65%) of title compound a white solid, mp 36°-38° C.

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