반응 #43332

반응 방정식

Trifluoroacetic acid

4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

수율 92.7%

4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one

수율 92.7%

반응 조건

후처리

1. 1
   농축After concentrating
2. 2
   기타the reaction liquid under reduced pressure, chloroform
3. 3
   workup.ADDITIONwas added to the reaction liquid which
4. 4
   세척then was washed with aqueous sodium hydrogencarbonate solution
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   농축Concentrating the solvent under reduced pressure

실험 절차

Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.

출처