반응 #43330

반응 방정식

2,5-dichloropyridine

potassium vinyltrifluoroborate

triethylamine

ethanol

→

title compound

수율 69.0%

5-chloro-2-vinylpyridine

수율 69.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   세척by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine
3. 3
   건조drying over anhydrous sodium sulfate
4. 4
   농축Concentrating the solvent under reduced pressure
5. 5
   workup.DISTILLATIONthe resulting residue was distilled under reduced pressure (63° C., 8 mmHg)

실험 절차

A mixture of 2,5-dichloropyridine (10.0 g), potassium vinyltrifluoroborate (10.86 g), dichloromethane complex (2.5 g) of dichloro-1,1′-bis(diphenylphosphino)-ferrocene palladium (II), triethylamine (14.13 mL) and ethanol (150 mL) was stirred overnight under reflux. After cooling the system to room temperature, ethyl acetate was added, followed by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine and drying over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was distilled under reduced pressure (63° C., 8 mmHg) to provide the title compound (6.50 g, 69%).

출처