반응 #43317

반응 방정식

THF

4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

수율 74.6%

4-hydroxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

수율 74.6%

용매

hydrogen

반응 조건

후처리

1. 1
   기타The reaction liquid
2. 2
   여과was filtered
3. 3
   세척washed thoroughly with methanol
4. 4
   농축the filtrate was concentrated under reduced pressure
5. 5
   workup.ADDITIONTHF was added to the resulting residue
6. 6
   여과the formed precipitate was recovered by filtration
7. 7
   기타dried

실험 절차

Into a THF (10 mL) solution of 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one (Example 2, 130 mg, 0.32 mmol), 10% palladium-on-carbon (165 mg) was added and stirred at room temperature for 10 hours in hydrogen atmosphere. The reaction liquid was filtered, washed thoroughly with methanol, and the filtrate was concentrated under reduced pressure. THF was added to the resulting residue and the formed precipitate was recovered by filtration and dried to provide the title compound (75 mg, 74%).

출처