반응 #43311

반응 방정식

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

2-(dimethylamino)ethanol

triphenylphosphine

diethyl azodicarboxylate

→

title compound

수율 66.6%

4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one

수율 66.6%

용매

THF

반응 조건

후처리

1. 1
   농축Concentrating
2. 2
   기타the reaction liquid under reduced pressure
3. 3
   기타the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10)

실험 절차

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).

출처