반응 #432815

반응 방정식

water

isopropyl alcohol

isopropanol

water

1-dodecylmercaptan

laurylmercaptan

sulfuric acid

→

3-dodecylthiopropionic acid

수율 98.2%

반응 조건

후처리

1. 1
   기타The same basic ingredients and quantities thereof were reacted
2. 2
   기타except the initial reaction composition
3. 3
   온도the composition was heated
4. 4
   온도to reflux
5. 5
   workup.ADDITIONAdding 25 ml
6. 6
   온도was refluxed for 3 hours
7. 7
   온도After cooling
8. 8
   workup.ADDITIONthe composition was poured into a separatory funnel
9. 9
   세척washed with three 100 mililiter aliquots of hot water with sodium sulfate

실험 절차

The same basic ingredients and quantities thereof were reacted as specified in Example 1, except the initial reaction composition included 75 ml. of isopropanol and 50 ml. of water. The resulting clear solution was cooled to 60° C., and the 1-dodecylmercaptan or laurylmercaptan was added during a 30-minute time period. No temperature change was noted, the composition was heated to reflux, and 25 ml. of water were added. Adding 25 ml. of isopropyl alcohol resulted in a clear solution, which was refluxed for 3 hours, moderate foaming being observed. After cooling, 58.3 grams of 50% aqueous sulfuric acid were added, and the composition was poured into a separatory funnel and washed with three 100 mililiter aliquots of hot water with sodium sulfate. Vacuum stripping yielded 134.5 grams of 3-dodecylthiopropionic acid product having a melting point of 60°-62.5° C., an acid value of 202.5 (204.4 theoretical), a laurylmercaptan percentage of 0.02%, and a yield of 98.2% by GLC.

출처