반응 #43278
ord-9bb50b18badf4dd7903ca55bbb1fedd2
반응 방정식
tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate
1,1-difluoro-4-iodomethylcyclohexane
ethyl 4,4-difluorocyclohexanecarboxylate
iodide
1-methyl-1H-pyrazol-3-amine
→
3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)propionamide
반응물
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 1-methyl-1H-pyrazol-3-amine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)propionamide.