반응 #432762

반응 방정식

ethyl 4-amino-5-cyano-2-methoxybenzoate

sodium hydroxide

→

4-amino-5-cyano-2-methoxybenzoic acid

수율 93.2%

용매

water

반응 조건

후처리

1. 1
   workup.STIRRINGstirring
2. 2
   온도The reaction mixture was cooled
3. 3
   여과filtered
4. 4
   여과The precipitated product was filtered off
5. 5
   세척washed thoroughly with water
6. 6
   기타dried overnight at 80° C.

실험 절차

A suspension of 10.69 parts of ethyl 4-amino-5-cyano-2-methoxybenzoate in 12 parts of a sodium hydroxide solution 50% and 500 parts of water was stirred and heated to 50° C. and stirring was continued for 1 hour at 50°-55° C. The reaction mixture was cooled and filtered. The filtrate was acidified with concentrated hydrochloric acid of pH 1-2. The precipitated product was filtered off, washed thoroughly with water and dried overnight at 80° C., yielding 8.6 parts (93.2%) of 4-amino-5-cyano-2-methoxybenzoic acid; mp. 236.7° C. (intermediate 111).

출처