반응 #432451

반응 방정식

hydrochloric acid

potassium tert-butylate

2-chloro-6-hydroxybenzoic acid

2-chloro-4,6-dimethoxytriazine

→

2-chloro-6-(4,6-dimethoxytriazin-2-yloxy)-benzoic acid

용매

dimethylformamide

water

반응 조건

후처리

1. 1
   추출Extraction
2. 2
   건조the extract is dried over sodium sulfate
3. 3
   기타the solvent is removed under reduced pressure
4. 4
   workup.STIRRINGThe residue is stirred with a small amount of diethyl ether
5. 5
   여과followed by filtration
6. 6
   기타The residue is dried under reduced pressure (m.p. 128°-131° C.)

실험 절차

At 25° C., 20.2 g of potassium tert-butylate is added in portions to 15.5 g of 2-chloro-6-hydroxybenzoic acid in 50 ml of dimethylformamide. Subsequently, 15.7 g of 2-chloro-4,6-dimethoxytriazine is added. The mixture is stirred for 12 hours at 25° C. and poured into cold water, and the resulting mixture is acidified with hydrochloric acid. Extraction is then carried out with ethyl acetate, and the extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is stirred with a small amount of diethyl ether, followed by filtration. The residue is dried under reduced pressure (m.p. 128°-131° C.).

출처