반응 #432155

반응 방정식

4-hydroxybiphenyl-4'-carboxylic acid

(S)-2-methylbutyl alcohol

p-toluenesulfonic acid

→

corresponding colorless compound

수율 41.0%

(S)-2-methylbutyl 4-hydroxybiphenyl-4'-carboxylate

수율 41.0%

반응 조건

후처리

1. 1
   여과Then the mixture was filtered
2. 2
   기타to remove the unreacted 4-hydroxybiphenyl-4'-carboxylic acid
3. 3
   기타Next, the filtrate was evaporated
4. 4
   workup.DISTILLATIONthe unreacted (S)-2-methylbutyl alcohol was distilled off
5. 5
   기타The crystals thus obtained
6. 6
   기타were recrystallized from 200 ml of n-hexane

실험 절차

3.75 g of 4-hydroxybiphenyl-4'-carboxylic acid was heated under reflux together with (S)-2-methylbutyl alcohol in the presence of 0.10 g of p-toluenesulfonic acid for about 6 hours. Then the mixture was filtered to remove the unreacted 4-hydroxybiphenyl-4'-carboxylic acid. Next, the filtrate was evaporated and the unreacted (S)-2-methylbutyl alcohol was distilled off. The crystals thus obtained were recrystallized from 200 ml of n-hexane. Thus, 2.05 g of the corresponding colorless compound was obtained (Yield: 41%).

출처