반응 #431172

반응 방정식

thiocarbohydrazide

4-(dodecylsulfonyl)butanoic acid

3-nitrobenzeneboronic acid

→

desired product

수율 87.4%

4-amino-3-[3-(dodecylsulfonyl)propyl]-5-mercapto-[1,2,4]triazole

수율 87.4%

용매

toluene

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도at reflux for 24 hr
3. 3
   온도Upon cooling
4. 4
   기타the thick precipitate was collected
5. 5
   세척rinsed with a small amount of acetonitrile (10 ml)
6. 6
   기타dried in vacuo

실험 절차

To a mixture of 4.9 g (47 mmol) of thiocarbohydrazide and 15 g (47 mmol) of 4-(dodecylsulfonyl)butanoic acid in 30 ml of toluene was added 0.8 g (4.7 mmol) of 3-nitrobenzeneboronic acid. The mixture was heated at reflux for 24 hr. Upon cooling, the thick precipitate was collected, rinsed with a small amount of acetonitrile (10 ml), dried in vacuo to yield 16 g (87.4%) of the desired product as a white solid. All of the analytical data confirmed the assigned structure.

출처