반응 #43082

ord-f5a63f1faa6d4985a180df4662fae4d8

반응 방정식

CC(=O)c1cccc(-c2ccnc(Cl)n2)c1
Intermediate 38
CC(=O)c1cccc(-c2ccnc(Cl)n2)c1
1-[3-(2-Chloro-pyrimidin-4-yl)-phenyl]-ethanone
COc1ccc(CCN)cc1
2-(4-Methoxy-phenyl)-ethylamine
→
COc1ccc(CCNc2nccc(-c3cccc(C(C)=O)c3)n2)cc1
1-(3-{2-[2-(4-Methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-ethanone

반응물

CC(=O)c1cccc(-c2ccnc(Cl)n2)c1
Intermediate 38
CC(=O)c1cccc(-c2ccnc(Cl)n2)c1
1-[3-(2-Chloro-pyrimidin-4-yl)-phenyl]-ethanone
COc1ccc(CCN)cc1
2-(4-Methoxy-phenyl)-ethylamine
—
348

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Intermediate 38 was coupled with 2-(4-Methoxy-phenyl)-ethylamine following procedure F. LC-MS showed the product had the expected M+H+ of 348.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07732444B2uspto-grants-2010_06