반응 #43076

ord-717a36b195fc45dfabe1675aacd40eca

반응 방정식

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
CC(C)(C)OC(=O)N1CCC(N)C1
3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CCC(NCc2cccc(-c3ccnc(Cl)n3)c2)C1
3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

반응물

O=Cc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 1
O=Cc1cccc(-c2ccnc(Cl)n2)c1
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
CC(C)(C)OC(=O)N1CCC(N)C1
3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester
—
389

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Intermediate 1 was coupled with 3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 389.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07732444B2uspto-grants-2010_06