반응 #430490

반응 방정식

3-hydroxy-17-methyleneestra-1,3,5(10)-triene-2-carboxaldehyde

hydrogen

→

27

수율 76.2%

3-hydroxy-17β-methylestra-1,3,5(10)-triene-2-carboxaldehyde

수율 76.2%

용매

EtOAc

반응 조건

후처리

1. 1
   여과After the catalyst was filtered
2. 2
   기타the solvent was evaporated at reduced pressure
3. 3
   기타The residue was purified by column chromatography (silica gel)

실험 절차

To a solution of 3-hydroxy-17-methyleneestra-1,3,5(10)-triene-2-carboxaldehyde (23, 0.401 g, 1.35 mmol) in EtOAc (10 mL) was added 10% palladium on carbon (0.060 g). The reaction mixture was stirred for 4 h under the hydrogen atmosphere at room temperature. After the catalyst was filtered, the solvent was evaporated at reduced pressure. The residue was purified by column chromatography (silica gel) using n-hexane:EtOAc (10:1→2:1, v/v) to afford 0.307 g of 27 (76% yield).

출처