반응 #430308

반응 방정식

H2O

N-Phenyl phenylenediamine

K2CO3

Bromomethyl-N-isopropyl-N-(4-trifluoromethyl-phenyl) acetamide

→

N-Isopropyl-2-(2-phenylamino-phenylamino)-N-(4-trifluoromethyl-phenyl)-acetamide

수율 75.9%

용매

DMF

반응 조건

후처리

1. 1
   온도then is heated to 50° C. for 16 h
2. 2
   온도The reaction mixture is then cooled to RT
3. 3
   추출extracted with Et2O (2×100 mL)
4. 4
   세척The organic layers were washed in series with 1N HCl (2×80 mL), NaHCO3 (1×80 mL), and H2O (1×80 mL)
5. 5
   건조dried (MgSO4)
6. 6
   기타the solvent removed in vacuo
7. 7
   기타Purification of the crude material by silica gel flash column chromatography

실험 절차

To a stirred solution of 1.16 g (6.32 mmol) of N-Phenyl phenylenediamine in 15 mL of DMF is added 1.05 g (7.58 mmol, 1.2 equiv) of K2CO3 and 2.05 g (6.32 mmol) of Bromomethyl-N-isopropyl-N-(4-trifluoromethyl-phenyl) acetamide. The resulting mixture is stirred 1 h at RT then is heated to 50° C. for 16 h. The reaction mixture is then cooled to RT, poured into 100 mL H2O and extracted with Et2O (2×100 mL). The organic layers were washed in series with 1N HCl (2×80 mL), NaHCO3 (1×80 mL), and H2O (1×80 mL), dried (MgSO4), and the solvent removed in vacuo. Purification of the crude material by silica gel flash column chromatography using hexane/EtOAc 5/1 as eluent afforded 2.05 g of N-Isopropyl-2-(2-phenylamino-phenylamino)-N-(4-trifluoromethyl-phenyl)-acetamide as a light tan solid: 1H NMR (CDCl3, 400 MHz) δ7.72 (d, 2H, J=8.2), 7.26 (d, 2H, J=8.2), 7.15 (m, 3H), 6.95 (dd, 1H, J=7.7, 7.7), 6.80 (dd, 1H, J=7.1, 7.1), 6.74 (d, 2H, J=7.9), 6.68 (dd, 1H, J=7.4, 7.4), 6.29 (d, 1H, J=7.9), 5.20 (s, 1H), 5.00 (m, 1H), 3.40 (s, 2H), 1.06 (d, 6H, J=6.6); low resolution MS (FAB)m/e 427 (MH+); high resolution MS (C24H24F3N3O) Calc. 427.1871 Found 427.1871.

출처