반응 #43023

반응 방정식

Intermediate 6

3-(2-Chloro-pyrimidin-4-yl)-phenylamine

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

→

3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

수율 70.0%

반응 조건

후처리

1. 1
   기타The product was purified on silica gel using 1:1 ethyl acetate

실험 절차

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

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