반응 #430112
ord-a287f31b9303459e8fd267ab8b600b01
반응 방정식
(S)-2-(6-methoxy-2-naphthyl)propionic acid
sodium hydroxide
→
naproxen sodium
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
It has been found that, surprisingly, when neutralizing (S)-2-(6-methoxy-2-naphthyl)propionic acid having a chiral purity below 99% with less than a stoichiometric amount of aqueous sodium hydroxide solution to form naproxen sodium, it is possible to increase the chiral purity of the naproxen sodium to 99% or more by removing the water by use of a suitable organic solvent, or simply by distilling off water from an aqueous solution.