반응 #429749

반응 방정식

1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine

3-(3-chloropropyl)-1-cyclohexylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione

→

1-cyclohexylmethyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

반응 조건

실험 절차

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-1-cyclohexylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-cyclohexylmethyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 130°-132° C.; Anal.: Calcd. for C27H37F3N4O3.HCl: C, 57.99; H, 6.88; N, 10.02%; Found: C, 58.01; H, 6.80; N, 9.87%;

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