반응 #4297

반응 방정식

2-chloroethylphenyl sulfone

methylamine

→

title compound

N-Methyl-2-(phenylsulfonyl)ethanamine

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The solvent is removed in vacuo
2. 2
   기타the residue is partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   추출The methylene chloride solution is extracted with dilute sulfuric acid
4. 4
   추출The acidic extract
5. 5
   추출the basic solution is extracted with methylene chloride
6. 6
   건조The methylene chloride solution is dried over magnesium sulfate
7. 7
   기타the solvent is removed in vacuo

실험 절차

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

출처