반응 #429691

반응 방정식

4,6-dichloro-5-methoxypyrimidine

2-(4-chlorophenyl)ethanol

sodium hydride

ammonium chloride

hydrogen

→

4-[2-(4-chlorophenyl)ethoxy]-5-methoxy-6-chloropyrimidine

수율 88.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITION96, 1661 (1965) were added in portions
2. 2
   추출extracted with diethyl ether
3. 3
   건조The combined organic phase was dried over magnesium sulfate
4. 4
   농축concentrated in vacuo
5. 5
   기타The residue was chromatographed on silica gel

실험 절차

2.40 g (15.2 mmol) of 2-(4-chlorophenyl)ethanol were added dropwise at 40° C. to a suspension of 680 mg (22.7 mmol) of sodium hydride (80% suspension in oil) in 40 ml of dry tetrahydrofuran, and the mixture was stirred until the evolution of hydrogen had ceased. The mixture was then allowed to cool to room temperature, whereupon 2.7 g (15.2 mmol) of 4,6-dichloro-5-methoxypyrimidine (Monatshefte Chem. 96, 1661 (1965) were added in portions. The mixture was stirred for 1 hour at room temperature and for 4 hours at 40° C. For work-up, the reaction mixture was poured into saturated ammonium chloride solution and extracted with diethyl ether. The combined organic phase was dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel using n-heptane/ethyl acetate (4:1). 4.0 g (88% of theory) of 4-[2-(4-chlorophenyl)ethoxy]-5-methoxy-6-chloropyrimidine was obtained in the form of a viscous oil which crystallized slowly upon drying (melting point 70°-71° C.).

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