반응 #429587

반응 방정식

D-tryptophan methyl ester hydrochloride

triethylamine

piperonyloyl chloride

→

title compound

수율 100.2%

(R)-Nα -(3,4-Methylenedioxyphenylcarbonyl)-tryptophan methyl ester

수율 100.2%

용매

CH2Cl2

반응 조건

후처리

1. 1
   세척The mixture was washed successively with water, 0.5N hydrochloric acid, water
2. 2
   건조After drying over Na2SO4 and evaporation of the solvent under reduced pressure

실험 절차

To a suspension of D-tryptophan methyl ester hydrochloride (10.2 g) in anhydrous CH2Cl2 (150 ml) cooled at 0° C. was added dropwise triethylamine (12.3 ml). To the resulting solution solid piperonyloyl chloride (8.16 g) was added portionwise at the same temperature, and the mixture was stirred at room temperature for 2 h. The mixture was washed successively with water, 0.5N hydrochloric acid, water, a saturated aqueous solution of NaHCO3 and again with water. After drying over Na2SO4 and evaporation of the solvent under reduced pressure, the resulting oil on trituration from hot cyclohexane afforded the title compound as a white solid (14.7 g).

출처