반응 #429377

반응 방정식

6-methoxy-3-methyl-benzo[d]isothiazole

(E)-1,4-dibromobutene

N-allyl-methyl-amine

→

3-methyl-benzo[d]isothiazol-6-ol

(E)-6-(4-bromo-but-2-enyloxy)-3-methyl-benzo[d]isothiazole

(E)-allyl-methyl-[4-(3-methyl-benzo[d]isothiazol-6-yloxy)-but-2-enyl]-amine

반응 조건

실험 절차

from 6-methoxy-3-methyl-benzo[d]isothiazole (intermediate in Ex. 2d), after cleavage of the methoxy protecting group, reaction with (E)-1,4-dibromobutene and N-allyl-methyl-amine and salt formation, via 3-methyl-benzo[d]isothiazol-6-ol and via (E)-6-(4-bromo-but-2-enyloxy)-3-methyl-benzo[d]isothiazole there is obtained (E)-allyl-methyl-[4-(3-methyl-benzo[d]isothiazol-6-yloxy)-but-2-enyl]-amine.fumarate (1:1), MS: m/e 289 (M+H+),

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