반응 #429280

반응 방정식

2,3-dihydrobenzodioxin-5-carboxaldehyde

malonic acid

pyrrolidine

→

(trans)-3-(2,3-Dihydrobenzodioxin-5-yl)propenoic acid

용매

pyridine

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux for 2 hr
3. 3
   온도cooled
4. 4
   여과The white precipitate was filtered
5. 5
   세척washed with 1N HCl, and air
6. 6
   기타dried (9.83 g, 84.6%)

실험 절차

A mixture of 2,3-dihydrobenzodioxin-5-carboxaldehyde (Morishima, et al., Eur. Pat. Appl. 309,766, 5 Apr. 89) (9.25 g, 56.4 mmol), malonic acid (11.73 g, 112.8 mmol), pyrrolidine (1 mL), and pyridine (25 mL) was heated to reflux for 2 hr, cooled, and then poured into ice water (300 mL). The white precipitate was filtered, washed with 1N HCl, and air dried (9.83 g, 84.6%).

출처