반응 #42885

반응 방정식

4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

sodium hydroxide

HCl

→

4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid

수율 71.0%

용매

—

mixture

THF water

반응 조건

후처리

1. 1
   기타The precipitate was isolated
2. 2
   세척washed with water
3. 3
   기타dried in vacuo

실험 절차

To a solution of 4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (75 mg) in 2.5 mL of a mixture of THF:water (1.5:1) was added sodium hydroxide (0.442 mL, 1 M, 2.2 eq) and the reaction mixture was stirred for 24 hours at room temperature. Then the reaction mixture was acidified by addition of a solution of aqueous HCl (0.442 mL, 1N, 2.2 eq). The precipitate was isolated, washed with water and dried in vacuo to yield 4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid (51 mg, 71%) as a white solid.

출처