반응 #4285

반응 방정식

1-chloro-3-(p-chlorophenylsulfonyl)propane

potassium phthalimide

→

2-[3-[(4-Chlorophenyl)sulfonyl]propyl]-1,3-dihydro-2H-isoindole-1,3-dione

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타quenched in water
2. 2
   추출The mixture was extracted with methylene chloride
3. 3
   건조the methylene chloride layer dried over magnesium sulfate
4. 4
   workup.ADDITIONDiethylether and hexane were added
5. 5
   기타The crystalline product was recrystallized from methylene chloride diethyl ether
6. 6
   기타to give a white crystalline product, m.p. 187.5°-188.5° C.

실험 절차

A solution of 17.8 g (0.07 mole) of 1-chloro-3-(p-chlorophenylsulfonyl)propane and 15.2 g (0.082 mole) of potassium phthalimide in 300 ml of dimethylformamide was stirred at 90°-110° C. for 2 hr and then quenched in water. The mixture was extracted with methylene chloride and the methylene chloride layer dried over magnesium sulfate. Diethylether and hexane were added and the solution stored at 0° C. overnight. The crystalline product was recrystallized from methylene chloride diethyl ether to give a white crystalline product, m.p. 187.5°-188.5° C.

출처