반응 #428350

반응 방정식

4-(4-Bromo-phenoxy)-piperidine

Na2CO3

(BOC)2O

→

product

수율 86.4%

4-(4-Bromo-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

수율 86.4%

용매

dioxane

water

반응 조건

후처리

1. 1
   기타Reaction
2. 2
   기타solvent was removed under reduced pressure and residue
3. 3
   기타partitioned between EtOAc and water the layers
4. 4
   기타were separated
5. 5
   세척The organic layer was washed with brine
6. 6
   건조dried (MgSO4)
7. 7
   농축concentrated under reduced pressure

실험 절차

To a solution of 4-(4-Bromo-phenoxy)-piperidine (1 g, 3.9 mmol) in dioxane (20 ml), water (20 ml) added Na2CO3 (1.6 g, 18.9 mmol) and (BOC)2O (1.3 g, 5.9 mmol). Reaction stirred at ambient for 48 hours, solvent was removed under reduced pressure and residue partitioned between EtOAc and water the layers were separated. The organic layer was washed with brine, dried (MgSO4), and concentrated under reduced pressure to give (1.2 g) of product.

출처