반응 #42784

반응 방정식

isobutyryl chloride

2-(4-chlorophenyl)-1-(4-fluoro-2-hydroxy-phenyl)-ethanone

triethylamine

→

title compound

Isobutyric acid 2-[2-(4-chlorophenyl)-acetyl]-5-fluoro-phenyl ester

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   세척The organic phase is washed with 0.5 M HCl, water and brine
2. 2
   건조dried (MgSO4)
3. 3
   기타The solvent is removed in vacuo
4. 4
   기타the product is purified by flash chromatography on silica gel

실험 절차

To a solution of 2-(4-chlorophenyl)-1-(4-fluoro-2-hydroxy-phenyl)-ethanone (16.0 g, 60.6 mmol) in CH2Cl2 (300 ml) is added triethylamine (7.4 g, 72.7 mmol). A solution of isobutyryl chloride (7.1 g, 66.6 mmol) in CH2Cl2 (100 ml) is added slowly over 30 min. The reaction mixture is stirred at room temperature for 2 h. The organic phase is washed with 0.5 M HCl, water and brine and dried (MgSO4). The solvent is removed in vacuo, and the product is purified by flash chromatography on silica gel using iso-hexane:ethyl acetate (20:1 to 10:1) as the eluent to give the title compound.

출처