반응 #42765

반응 방정식

water

3-Bromo-2-isopropyl-7-(4-methoxybenzylamino)-8-nitro-chromen-4-one

4-chlorophenylboronic acid

sodium carbonate

→

3-(4-Chlorophenyl)-2-isopropyl-7-(4-methoxybenzylamino)-8-nitro-chromen-4-one

용매

ethanol

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (3×30 ml)
2. 2
   세척washed with saturated brine (30 ml)
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   기타to give a green solid
7. 7
   기타This is triturated with n-pentane
8. 8
   여과filtered
9. 9
   기타to give a pale yellow powder

실험 절차

3-Bromo-2-isopropyl-7-(4-methoxybenzylamino)-8-nitro-chromen-4-one (105 mg, 0.235 mmol), 4-chlorophenylboronic acid (73 mg, 0.47 mmol) and tetrakis(triphenylphosphine) palladium (0) (28 mg, 0.024 mmol) are dissolved in absolute ethanol (3 ml) in a 5 ml capacity microwave tube. Aqueous sodium carbonate solution (2M, 0.35 ml, 0.7 mmol) is added, and the mixture is heated at 100° C. under microwave irradiation for 10 min. The mixture is poured into water (10 ml) and extracted with ethyl acetate (3×30 ml). The ethyl acetate extracts are combined, washed with saturated brine (30 ml), dried (MgSO4), filtered and evaporated to give a green solid. This is triturated with n-pentane and filtered to give a pale yellow powder.

출처