반응 #427403
ord-de248117621e4c63ae8d5cb3e3b3d08a
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The reaction was quenched with saturated aqueous NaHCO3 solution
- 2추출extracted with dichloromethane three times
- 3건조The combined organic layers were dried over anhydrous MgSO4
- 4농축concentrated en vacuo
- 5기타The crude residue was purified by a COMBIFLASH® system (ISCO)
실험 절차
A solution of 3-(benzyloxy)-5-bromopyridine (from step 1) (1.0 eq.) and meta-chloroperbenzoic acid (mCPBA) (4.0 eq.) in dichloromethane (0.1 M) was stirred at room temperature for 18 hours. The reaction was quenched with saturated aqueous NaHCO3 solution and extracted with dichloromethane three times. The combined organic layers were dried over anhydrous MgSO4 and concentrated en vacuo. The crude residue was purified by a COMBIFLASH® system (ISCO) using 0-100% ethyl acetate in hexane to give 3-(benzyloxy)-5-bromopyridine 1-oxide.